This award enabled Stephen and Tyler to attend the prestigious Advanced Analytical Ultracentrifugation Workshop and Symposium in Danbury, CT. The Advanced AUC workshop is a leading scientific event for promoting training, collaboration, and innovation in the field of protein interaction science and technology. Continue reading
Join us Tuesday, November 1st as we welcome Yasuf Hannun, MD, from Stony Brook University.
Thesis title: “Surfing on Pedestals: How Pathogenic E. coli Spreads Infection.”
The annual North East Structure Symposium (NESS) is devoted on contemporary topics in structural biology. The meeting will be held Friday, October 14 in the Grossman Auditorium, 400 Farmington Ave. on the UConn Health campus with a focus on “New Paradigms in Drug Discovery.” Go to http://ness.nmrbox.org/ for a list of speakers and registration information.
Centromeres ensure the correct segregation of chromosomes during cell division and are fundamental to genome evolution. While expansions of DNA within centromeres are known for many species, most centromeres are stable over evolutionary time and are relatively uniform across all centromeres in one genome. Thus, decoupling the equilibration events that occur across chromosomes from the initial seeding events specific to a subset of chromosomes has not been possible in most model systems. This research capitalizes on the recently discovered centromeric expansion of a selfish element, the LAVA retroelement, in a subset of chromosomes in one gibbon genus (Hoolock). Collectively, this funded work will delineate the impact of the organization and function of selfish elements (and conflict) among newly seeded centromeres and stabilized centromeres within one karyotype.
In collaboration with Lucia Carbone, Oregon Health Science Center.