COR²E is the old Biotechnology/Bioservices Center renamed, transformed, expanded, and just generally better! Fundamentally, we promote and support the growth of research at UConn by serving the University’s world-class research faculty (as well as the rest of the UConn community).
Resources and Equipment (COR²E) serves as the gateway to research resources available to the UConn community. In addition to providing a variety of software tools for exploring UConn research and expertise, COR²E is also the managing entity for a wide variety of core facilities, housing both state-of-the-art equipment and expertise.
Advanced Light Microscopy
The Advanced Light Microscopy Facility provides access to advanced imaging technology in order to promote innovation and cross-disciplinary interaction. The facility houses a number of laser scanning confocals, as well as systems for widefield imaging and total internal reflection microscopy.
The Biophysics Facility consists of analytical ultracentrifugation, microcalorimetry, and protein x-ray crystallography facilities. These facilities support research specializing in the study of characteristics of molecules and proteins and the interaction between molecules. The use of protein structures in the investigation of interesting biological, pharmaceutical and chemical questions has become increasingly prevalent over the past two decades.
The BioSupply Facility provides biological research supply services and stock room capabilities. The mission of the facility is to simplify research supply ordering and receiving. In addition to maintaining a constant stock of commonly utilized consumables, the facility works with a wide variety of vendors to provide cost savings to faculty on equipment and reagents.
Center for Genome Innovation (CGI)
The Center for Genome Innovation (CGI) provides state-of-the-art expertise in genome technologies like Next Generation Sequencing (NGS) and microfluidics platforms for single-cell genomic analysis while facilitating genomics research at UConn.
Computational Biology Core (CBC)
Computational Biology Core is striving to provide researchers with access to appropriate computational resources, as well as educate and train them on the use of bioinformatics software. The consultation service is available to faculty and students within the University system at no cost. The core also provides data analysis services at reasonable rates to both internal and external customers.
The Flow Cytometry Facility provides investigators with access to sophisticated instruments designed to detect and measure fluorescent light emission. The flow cytometers distinguish cells or particles based on size, internal complexity, and fluorescent signals. Cells or particles can also be sorted to obtain pure populations for further analysis or subsequent culture.
Microbial Analysis, Resources, and Services (MARS)
The Microbial Analysis, Resources and Services (MARS) facility supports research specializing in the analysis of microbial samples and high-throughput processing of nucleic acids. Examples include the characterization of microbiomes, sequencing of small genomes, 96-well and 384-well PCR setup or DNA quantification and other automated liquid handling applications.
Nuclear Magnetic Resonance (NMR)
The Nuclear Magnetic Resonance Facility (NMR) recognizes the important role that NMR plays in molecular structure determination, drug design, protein and nucleic acid characterization, and conformational analysis. The instrumentation serves the high-resolution research needs for investigators from the Departments of Molecular and Cell Biology, Chemistry, and Pharmacy at the University of Connecticut.
Proteomics & Metabolomics
The Proteomics & Metabolomics Facility implements ultra-high performance liquid chromatography (UPLC) coupled to high resolution mass spectrometry (MS) to unambiguously identify proteins, peptides and small molecules in complex mixtures.