The instrument, which accommodates 12-well to 384-well plates and is temperature controlled, can acquire the following kinds of signals: absorbance, fluorescence (all wavelengths, as it is monochrometer based), and luminescence. We have add-on modules that add time resolved fluorescence and fluorescein and rhodamine fluorescence anisotropy measurements. We have adaptors for doing nano volume nucleic acid quantification in 96-well format, and the instrument is also capable of acquiring chemiluminescent western blots.