Jonathan Klassen

klassenjl
Assistant Professor

University of Connecticut
Department of Molecular & Cell Biology
91 North Eagleville Road, Unit 3125
Torrey Life Sciences 279C
Storrs, CT 06269-3125

Telephone: 860-486-6890
Fax:  860-486-4331
jonathan.klassen@uconn.edu
Twitter-Klassen
Visit Assistant Profesor Klassen’s Website.

Education: PhD: Microbiology and Biotechnology, University of Alberta; Postdoctoral Study: Bacteriology, University of Wisconsin-Madison.

Research Interests: My research studies microbial community ecology, especially using the fungus-growing ant symbiosis as a model system to understand how microbial interaction networks evolve across ecological gradients. I am particularly interested in how the differing ecologies and population structures of multiple symbiotic partners affect the stability and function of their overall symbioses, and couple genomics and chemical biology both to understand the molecular mechanisms underpinning such interactions and to exploit them for drug discovery.

Selected Publications:

Christine Beemelmanns, Timothy R. Ramadhar, Ki Hyun Kim, Jonathan L. Klassen, Shugeng Cao, Thomas P. Wyche, Yanpeng Hou, Michael Poulsen, Tim S. Bugni, Cameron R. Currie, and Jon Clardy (2017) Macrotermycins A–D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39. Organic Letters, DOI: 10.1021/acs.orglett.6b03831.

Wyche TP, Ruzzini AC, Beemelmanns C, Kim KH, Klassen JL, Cao S, Poulsen M, Bugni TS, Currie CR, Clardy J (2017) Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides. Organic Letters, DOI:10.1021/acs.orglett.7b00545

Kopac SM and Klassen JL (2016) Can They Make It on Their Own? Hosts, Microbes, and the Holobiont Niche. Front. Microbiol. 7:1647. doi: 10.3389/fmicb.2016.01647.

Samantha M. Gromek, Anne A. Sung, Jonathan L. Klassen, Marcy J. Balunas (2016). Draft Genome Sequence of Streptomyces sp. Strain PTY087I2, Isolated from Styela canopus, a Panamanian Tunicate. Genome Announc. September/October 2016 vol. 4 no. 5 e00856-16. doi: 10.1128/genomeA.00856-16.

Theis KR, Dheilly NM, Klassen JL, Brucker RM, Baines JF, Bosch TCG, Cryan JF, Gilbert SF, Goodnight CJ, Lloyd EA, Sapp J, Vandenkoornhuyse P, Zilber-Rosenberg I, Rosenberg E, Bordenstein SR. 2016. Getting the hologenome concept right: an eco-evolutionary framework for hosts and their microbiomes. mSystems 1(2):e00028-16. doi:10.1128/mSystems.00028-16.

Rischer M, Klassen JL, Wolf T, Guo H, Shelest E, Clardy J, Beemelmanns C. 2016. Draft genome sequence of Shewanella sp. strain P1-14-1, a bacterial inducer of settlement and morphogenesis in larvae of the marine hydroid Hydractinia echinata. Genome Announc 4(1):e00003-16. doi:10.1128/genomeA.00003-16.

Jonathan L Klassen, Maja Rischer, Thomas Wolf, Huijuan Guo, Ekaterina Shelest, Jon Clardy, Christine Beemelmanns  Genome Sequences of Three Pseudoalteromonas Strains (P1-8, P1-11, and P1-30), Isolated from the Marine Hydroid Hydractinia echinata (2015) Genome Announcements 3(6): e01380-15

Jonathan L Klassen, Thomas Wolf, Maja Rischer, Huijuan Guo, Ekaterina Shelest, Jon Clardy, Christine Beemelmanns Draft genome sequences of six Pseudoalteromonas strains, P1-7a, P1-9, P1-13-1a, P1-16-1b, P1-25, and P1-26, which induce larval settlement and metamorphosis in Hydractinia echinata (2015) Genome Announcements 3(6): e01477-15

Murfin, K.E., Whooley, A.C., Klassen, J.L., Goodrich-Blair, H. Comparison of Xenorhabdus bovienii bacterial strain genomes reveals diversity in symbiotic functions. 2015. BMC Genomics doi:10.1186/s12864-015-2000-8.

Medema, M.H. et al. [150 authors, including Klassen, J.L.] 2015. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. Nat Chem Biol 11:625-631

Murfin KE, Lee M, Klassen JL, McDonald BR, Larget B, Forst S, Stock SP, Currie CR, Goodrich-Blair H. 2015. Xenorhabdus bovienii strain diversity impacts coevolution and symbiotic maintenance with Steinernema spp. nematode hosts. mBio 6(3):e00076-15. doi:10.1128/mBio.00076-15.

Klassen, JL (2014) Microbial secondary metabolites and their impacts on insect symbioses. Current Opinion in Insect Science. DOI: 10.1016/j.cois.2014.08.004 [Epub ahead of print].
Klassen, J. L. and Currie, C. R. 2013. ORFcor: identifying and accommodating ORF prediction inconsistencies for phylogenetic analysis. PLoS One 8(3): e58387 (link)

Klassen, J. L. and Currie, C. R. 2012. Gene fragmentation in bacterial draft genomes: extent, consequences and mitigation. BMC Genomics 13: 14 (link) (“Highly Accessed”)

Siddique,T., Penner, T., Klassen, J., Nesbø, C. and Foght, J. M. 2012. Microbial communities involved in methane production by oil sands tailings. Environ. Sci. Technol. 46 (17): 9802-9810 (link)

Pitre, M. C., Mayne Correia, P., Mankowski, P. J., Klassen, J. L., Day, M. J., Lovell, N. C. and Currah, R. 2012. Biofilm Growth in human skeletal material from Ancient Mesopotamia. J. Archaeol. Sci. 40 (1): 24-29 (link)

Carr, G., Poulsen, M., Klassen, J. L., Hou, Y., Wyche, T. P., Bugni, T. S., Currie, C. R. and Clardy, J. 2012. Microtermolides A and B from termite-associated Streptomyces sp. and structural revision of vinylamycin. Org. Lett. 14 (11): 2822-2825 (link)

Hou, Y., Braun, D. R., Michel, C. R., Klassen, J. L., Adnani, N., Wyche, T. P. and Bugni, T. S. 2012. UHPLC/HRMS-based secondary metabolomics as a broadly useful tool for rapid analysis of microbial natural products. Anal. Chem. 84 (10): 4277-4283 (link)

Klassen, J. L., Adams, S. M., Bramhacharya, S., Giles, S. S., Goodwin, L. A., Woyke, T. and Currie, C. R. 2011. Draft genome sequence of Streptomyces sp. Wigar10, isolated from a surface-sterilized garlic bulb. J. Bacteriol. 193 (24): 6999-7000

Grubbs, K. J., Biedermann, P. H. W., Suen, G., Adams, S., Moeller, J. A., Klassen, J. L., Goodwin, L. A., Woyke, T., Munk, A. C., Bruce, B., Detter, C., Tapia, R., Han, C. S. and Currie, C. R. 2011. The complete genome sequence of Streptomyces griseus strain XyelbKG-1, an ambrosia beetle—associated actinomycete. J. Bacteriol. 193 (11): 2890-2891(link)

Klassen, J. L. and Foght, J. M. 2011. Characterization of Hymenobacter isolates from Victoria Upper Glacier, Antarctica reveals five new species and substantial non-vertical evolution within this genus. Extremophiles 11 (1): 45-57 (link)

Barker, J. D., Klassen, J. L., Sharp, M. J., Fitzsimons, F. J. and Turner, R. J. 2010. Detecting biogeochemical activity in basal ice using fluorescence spectroscopy. Ann. Glaciol. 51 (56): 47-55 (link)

Klassen, J. L. 2010. Phylogenetic and evolutionary patterns in microbial carotenoid biosynthesis are revealed by comparative genomics. PLoS One 5 (6): e11257 (link)

Klassen, J. L. 2009. Pathway evolution by horizontal transfer and positive selection is accommodated by relaxed negative selection upon upstream pathway genes in purple bacterial carotenoid biosynthesis. J. Bacteriol. 191 (24): 7500-7508 (link)

Klassen, J. L., McKay, R. and Foght, J. M. 2009. 2ʹ-Methyl and 1ʹ-xylosyl derivatives of 2ʹ-hydroxyflexixanthin are major carotenoids of Hymenobacter species. Tetrahedron Lett. 50 (22): 2656-2660 (link)

Aislabie, J., Jordan, S., Ayton, J., Klassen, J. L., Barker, G. M. and Turner, S. 2009. Bacterial diversity associated with ornithogenic soil of the Ross Sea region, Antarctica. Can. J. Microbiol. 55 (1): 21-36 (link)

Klassen, J. L. and Foght, J. M. 2008. Differences in carotenoid composition among Hymenobacter and related strains support a tree-like model of carotenoid evolution. Appl. Environ. Microbiol. 74 (7): 2016-2022 (link)