Melissa Durstin

Assistant Professor In-Residence - Waterbury

Molecular and Cell Biology

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Education:
Ph.D. Biomedical Sciences – University of Connecticut Health Center, Farmington, CT
Postdoctoral study – Dana Faber Cancer Institute, Boston MA
Leukemia Society of America Fellow

Publications:
Sattler, M., Salgia, R., Durstin, M.A., Prasad, K.V., and Griffin, J.D.  1997.  Thrombopoietin induces activation of the phosphatidylinositol-3′ kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL.  J. Cell. Physiol. 171, 28-33.

Durstin, M., Inhorn, R.I., and Griffin, J.D.  1996.  Tyrosine phosphorylation of shc is not required for proliferation or viability signaling by GM-CSF.  J. Immunol. 157, 534-540.

Sattler, M., Salgia, R., Okuda, K., Uemura, N., Durstin, M., Pisick, E., Xu, G., Li, J-L., Prasad, K.V., and Griffin, J.D.  1996.  The proto-oncogene p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3′ kinase pathway.  Oncogene 12, 839-846.

Sattler, M., Durstin, M.A., Frank, D.A., Okuda, K., Kaushansky, K., Salgia, R., and Griffin, J.D.  1995  The thrombopoietin receptor c-mpl activates JAK2 and TYK2 tyrosine kinases.  Exp. Hematol. 23, 1040-1048.

Inhorn, R.C., Carlesso, N., Durstin, M., Miyajima, A., and Griffin, J.D.  1995.  Identification of a viability domain in the granulocyte-macrophage colony-stimulating factor receptor b-chain involving tyrosine-750 and shc.  Proc. Natl., Acad., Sci. U.S.A. 92, 8665-8669.

Durstin, M. and Sha’afi, R.I.  1994.  Signal Transduction in the Human Neutrophil.  In Signal Transduction in Leukocytes:  Role of G Protein-Related and Other Pathways, Editors, Lad, P.M., Kaptein, J.S., and Lin, C-K.E., CRC Press, 253-285.

Durstin, M., Gao, J-L., Tiffany, H.L., McDermott, D., and Murphy, P.M.  1994.  Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes.  Biochem. Biophys. Res. Commun.  201, 174-179.

Durstin, M., Durstin, S., Molski, T.F.P., Becker, E.L., and Sha’afi, R.I.  1994.  Cytoplasmic phospholipase A₂ translocates to membrane fraction in human neutrophils activated by stimuli that phosphorylate MAP kinase.  Proc. Natl. Acad. Sci. U.S.A. 91, 3142-3146.

Sha’afi, R.I. and Durstin, M.  1994.  Role of the tyrosine phosphorylated MAPK in the activation of cPLA₂.  In Challenges in Modern Medicine, volume 3: Molecular basis of Inflammation, Editor, Navarro, J., Ares-serona Publications, 59-67.

Durstin, M. McColl, S.R., Gomez-Cambronero, J., Naccache, P.H., and Sha’afi, R.I.  1993.  Up-regulation of the amount of G_ia2 associated with the plasma membrane in human neutrophils stimulated by granulocyte-macrophage colony-stimulating factor.  Biochem. J. 292, 183-187.

Sha’afi, R.I., Gomex-Cambronero, J., Yamazaki, M., Durstin, M., Molski, T.F.P., and Huang, C.-K.  1990.  Activation of human neutrophils by granulocyte-macrophage colony-stimulating factor:  Role of guanine-nucleotide binding proteins.  In Biology of Cellular Transducing Signals, Editors, Vanderhoek, J.Y., Jelesma, C., and Moody, T.W., Plenum Press, 153-162.

Gomez-Cambronero, J., Durstin, M., Molski, T.F.P., Naccache, P.H., and Sha’afi, R.I.  1989.  Calcium is necessary but not sufficient for the platelet-activating factor release in human neutrophils stimulated by physiological stimuli:  Role of G-proteins.  J. Biol. Bhem. 264, 21699-21704.

Yamazaki, M., Gomez-Cambronero, J., Durstin, M., Molski, T.F.P., Becker, E.L., and Sha’afi, R.I.  1989.  Phorbol-12-myristate 13-acetate inhibits binding of leukotriene B4 and platelet-activating factor and the responses they induce in neutrophils:  Site of action.  Proc. Natl. Acad. Sci. U.S.A. 86, 5791-5794.