James Cole

Professor

Molecular and Cell Biology / Structural Biology, Biochemistry and Biophysics (SB3)


Education: Ph.D., University of California; Post-doctoral study, Stanford University.

Research Interests: We use biochemical, biophysical and structural methods to define the key macromolecular interactions that regulate important biological processes. Our major focus is the innate immunity pathway for defense against viral infection.

Selected Publications:

Zerbe, Cassie M, and Cole, James L. “Regulation of PKR by Epstein-Barr Virus EBER1 RNA.” Biochemistry.Ja (2020): Biochemistry. , 2020, (ja). Web.

Zerbe, C.M., Mouser, D.J. and Cole, J.L. (2019) Oligomerization of RIG-I and MDA5 2CARD Domains. Protein Science, in press.

Mayo, C.B., Erlandsen, H., Mouser, D.J., Feinstein, A.G., Robinson, V.L., May, E.R., Cole, J.L. (2019) Structural Basis of Protein Kinase R Autophosphorylation. Biochemistry 58, 2967-2977.

Cole, J.L. (2018) Catalytic Domains in RNA-Binding Proteins. In Roberts G., Watts A., European Biophysical Societies (eds.) Encyclopedia of Biophysics. Springer, Berlin, Heidelberg.

Pindrus, M.A., Cole, J.L., Kaur, J., Shire, S.J., Yadav, S. and Kalonia, D.S. (2017) Effect of aggregation on the hydrodynamic properties of bovine serum albumin. Pharm. Res.34, 2250-2259.

Mayo, C.B. and Cole, J.L. (2017) Interaction of PKR with single-stranded RNA. Sci. Rep.7, 3335.

Mayo, C.B., Wong, C.J., Lopez P.E., Lary, J.W., Cole, J.L. (2016) Activation of PKR by short stem-loop RNAs containing single-stranded arms. RNA 22, 1065-175.

Husain, B., Mayo, C. and Cole, J.L. (2015) Role of the interdomain linker in PKR activation. Biochemistry 55, 253-261.

Husain, B., Hesler, S. and Cole, J.L. (2015) Regulation of PKR by RNA: Formation of active and inactive dimers. Biochemistry 54, 6663-6672.

Launer-Felty, K., Wong, C.J. and Cole, J.L. (2014) Structural analysis of Adenovirus VAI RNA defines the mechanism of inhibition of PKR. Biophysical Journal 108, 748-757.

Kaus, K., Lary, J.W., Cole, J.L. and Olson, R. (2014) Glycan specificity of the Vibrio vulnificus hemolysin lectin outlines evolutionary history of membrane targeting by a toxin family. J. Mol. Biol. 426, 1285-1295.

Wowor, A.J., Yan, Y., Auclair, S.M., Yu, D., Zhang, J., May, E.R., Gross, M.L., Kendall, D.A. and Cole, J.L. (2014) Analysis of SecA Dimerization in Solution. Biochemistry 53, 3248-3260.

Launer-Felty, K. and Cole, J.L. (2014) Domain interactions in Adenovirus VAI mediate high-affinity PKR binding. J. Mol. Biol. 426, 1285-1295.

JamesCole
Contact Information
Emailjames.cole@uconn.edu
Phone860-486-4333
Fax860-486-4331
Mailing Address91 North Eagleville Road, Unit 3125, Storrs, CT 06269-3125
Office LocationBiology/Physics Building 205
Linkhttps://colelab.uconn.edu/