Arpita Ray

Assistant Professor In-Residence - Waterbury

Molecular and Cell Biology

Education: PhD., SUNY Downstate Medical Center; Postdoctoral Training, Icahn School of Medicine at Mt. Sinai

Research interests: Studying the unregulated cellular division that causes cancer. Analysis of checkpoints that usually control cell proliferation to better understand the molecular basis of cancer.   The principal task of the cell cycle is to ensure that a cell’s DNA is faithfully duplicated and evenly distributed to daughter cells. Loss of control over this process is a precursor to many medical and biological problems.

Selected Publications:

Ray, A., James, M.K., Larochelle, S., Fisher, R.P., Blain, S.W., “p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.” Mol. Cell Biol., Feb 2009; p. 986-999, Vol. 29, No. 4 https://doi.org/10.1128/MCB.00898-08

James M.K., Ray, A., Leznova, D. and Blain, S.W., “Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity.” Mol. Cell Biol., Jan 2008, p. 498-510, Vol. 28, No 1 https://doi.org/10.1128/MCB.02171-06

Abstracts:

Ray, A., Leznova, D., Blain, S.W., “p27KIP1’s dual role as an activator or inhibitor is dependent on signals provided by the arrested or cycling epithelial cell,” Cold Spring Harbor Meetings: The Cell Cycle, 2006, Cold Spring Harbor, NY

James, M., Leznova, D., Ray, A., Blain, S.W., “p27KIP1’s ability to inhibit or not to inhibit cyclin D-CDK4 may depend on cellular signals provided by arrested or cycling epithelial cell,” Cold Spring Harbor Meetings: The Cell Cycle, 2004, Cold Spring Harbor, NY