Andrei Alexandrescu


Molecular and Cell Biology / Structural Biology, Biochemistry and Biophysics (SB3)

Education: Ph.D. University of Wisconsin-Madison; Postdoctoral study, Oxford University; Johns Hopkins University Medical Institutes

Research Interests: High-resolution solution NMR investigations of protein structure, folding, evolution, dynamics, and association; Amyloids; Viruses; Metabolomics

Selected Publications:
[Click here to get nearly full publication list.]

Wayne Mitchell, Jeffrey D Tamucci, Emery L Ng, Shaoyi Liu, Alexander V Birk, Hazel H Szeto, Eric R May, Andrei T Alexandrescu, Nathan N Alder (2022) Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds eLife 11:e75531

Whitehead, R. D. III, Teschke, C.M., & Alexandrescu, A.T (2022) “Pulse-field gradient nuclear magnetic resonance of protein translational diffusion from native to non-native states”, Protein Sci, in press.

Kaplan, A.R., Olson, R. &Alexandrescu, A.T (2021) “Protein yoga: conformational versatility of the hemolysin II C-terminal domain detailed by NMR structures for multiple states”, Protein Sci, in press.

Dedeo, C.L., Teschke, C.M., & Alexandrescu, A.T(2020) “Keeping it together: structures, functions, and applications of viral decoration proteins”, Viruses 12, 1163.

Whitehead, R. D. III, Teschke, C.M., & Alexandrescu, A.T (2019) “NMR mapping of disordered segments for a viral scaffolding protein enclosed in a 23 MDa procapsid”, Biophysical J. 117: 1387-1392. DOI: 1016/j.bpj.2019.08.038

Newcomer, R.L., Schrad, J.R., Gilcrease, E.B., Casjens, S.R., Feig, M., Teschke, C.M., Alexandrescu, A.T, & Parent K.N. (2019) “The phage L capsid decoration protein has a novel OB-fold and an unusual capsid binding strategy”, eLife 8, e45345.

Tripler, T.N., Kaplan, A.R., Alexandrescu, A.T, & Teschke, C.M. (2019) “Conservation and divergence of the I-domain inserted into the ubiquitous HK97 coat protein fold in the P22-like bacteriophages”, Journal of Virology, 93: e0007-19. DOI: 10.1128/JVI.00007-19

Newcomer, R.L., Belato, H.B., Teschke, C.M. & Alexandrescu, A.T (2018) “NMR assignments for monomeric phage L decoration protein”, Biomolecular NMR Assignments 12, 339-343

Asthana, S., Mallick, B., Alexandrescu, A.T & Jha, S. (2017) “IAPP in type II diabetes: Basic research on structure, molecular interactions, and disease mechanisms suggests potential intervention strategies”, BBA Biomembranes (Special Issue on Protein Aggregation), 1860: 1765-1782

Anne R Kaplan, Katherine Kaus, Swastik De, Rich Olson & Andrei T Alexandrescu (2017) “NMR structure of the Bacillus cereus hemolysin II C-terminal domain reveals a novel fold.” Scientific Reports 7: 3277, DOI:

Anne R Kaplan, Megan R Brady, Mark W Maciejewski, Richard A Kammerer & Andrei T Alexandrescu (2017) “NMR Structures of GCN4p are Largely Conserved when Ion Pairs are Disrupted at Acidic pH but Show a Relaxation of the Coiled Coil Superhelix.” Biochemistry, 56, 1604-1619 , DOI: 10.1021/acs.biochem.6b00634 [Epub ahead of print]


Andrei Alexandrescu
Contact Information
Mailing Address91 North Eagleville Road, Unit 3125, Storrs, CT 06269-3125
Office LocationBiology/Physics Building 209