University of Connecticut
Department of Molecular & Cell Biology
91 North Eagleville Road, Unit-3125
Biology/Physics Building 205
Storrs, CT 06269-3125
Telephone: (860) 486-4333
Fax: (860) 486-4331
Education: Ph.D., University of California; Post-doctoral study, Stanford University.
Research Interests: Characterization of macromolecular interactions using analytical ultracentrifugation and related biophysical techniques. Double-stranded RNA activated protein kinase (PKR); interferon antiviral defense pathway; trp RNA-binding attenuation Protein (TRAP).
Pindrus, M.A., Cole, J.L., Kaur, J., Shire, S.J., Yadav, S. and Kalonia, D.S. (2017) Effect of aggregation on the hydrodynamic properties of bovine serum albumin. Pharm. Res. DOI:10.1007/s11095-017-2231-2
Mayo, C.B. and Cole, J.L. (2017) Interaction of PKR with single-stranded RNA. Sci. Rep.7, 3335
Mayo, C.B., Wong, C.J., Lopez P.E., Lary, J.W., Cole, J.L. (2016) Activation of PKR by short stem-loop RNAs containing single-stranded arms. RNA, DOI:10.1261/rna.053348.115.
Husain, B., Mayo, C. and Cole, J.L. (2015) Role of the interdomain linker in PKR activation. Biochemistry, in press, DOI:10.1021/acs.biochem.5b01171.
Husain, B., Hesler, S. and Cole, J.L. (2015) Regulation of PKR by RNA: Formation of active and inactive dimers. Biochemistry 54, 6663-6672.
Launer-Felty, K., Wong, C.J. and Cole, J.L. (2014) Structural analysis of Adenovirus VAI RNA defines the mechanism of inhibition of PKR. Biophysical Journal 108, 748-757.
Kaus, K., Lary, J.W., Cole, J.L. and Olson, R. (2014) Glycan specificity of the Vibrio vulnificus hemolysin lectin outlines evolutionary history of membrane targeting by a toxin family. J. Mol. Biol. 426, 1285-1295
Wowor, A.J., Yan, Y., Auclair, S.M., Yu, D., Zhang, J., May, E.R., Gross, M.L., Kendall, D.A. and Cole, J.L. (2014) Analysis of SecA Dimerization in Solution. Biochemistry 53, 3248-3260.
Launer-Felty, K. and Cole, J.L. (2014) Domain interactions in Adenovirus VAI mediate high-affinity PKR binding.J. Mol. Biol. 426, 1285-1295.
Yu, D., Wowor, A., Cole, J.L., and Kendall, D.A. (2013). Defining the Escherichia coli SecA Dimer Interface Residues through in Vivo Site-specific Photo-crosslinking.J. Bacteriol. 195, 2817-2825.
Ehlinger, A., Park, S., Fahmy, A., Lary, J.W., Cole, J.L., Finely, D., and Walters, K.J. (2013). Conformational Dynamics of the Rpt6 ATPase in Proteasome Assembly and Rpn14 Binding.Structure 21, 735-765
Cole, J.L, Correia, J.J. and Stafford, W.F. (2011) The use of analytical sedimentation velocity to extract thermodynamic linkage Biophys. Chem. 159, 120-128.
Wong, C.J., Launer-Felty, K. and Cole, J.L. (2011) Analysis of PKR-RNA interactions by sedimentation velocity. Methods Enzymol. 488, 59-79.