David Goldhamer
Sarah Hird

Please join us for Micro journal club on Sept. 27 at 4-5 pm in BPB 201. Dan Phillips will lead a discussion of:

Builders, tenants, and squatters: the origins of genetic material in modern stromatolites. Petryshyn et al., Geobiology. 2021 May;19(3):261-277. doi: 10.1111/gbi.12429.
https://onlinelibrary.wiley.com/doi/10.1111/gbi.12429

We will have a group discussion about the paper:
Chromosome errors in human eggs shape natural fertility over reproductive life span
https://www.science.org/doi/10.1126/science.aav7321

Everyone welcome

Dr. Beth Cimini, Senior Computational Biologist, Broad Institute of MIT and Harvard

Host: Stacey Hanlon

"Making the most of your microscopy data with high content image analysis"

Summary: The biology community is beginning to recognize images as a rich source of quantitative data, but many researchers find it difficult to do or aren’t sure exactly how to extract what they need. In this talk, we’ll discuss CellProfiler, a tool which makes it easier to extract hundreds or thousands of measurements from your microscopy data, as well as why you might want to extract that many in the first place.

Dr. Beth Cimini is a Senior Group Leader, CZI Imaging Scientist and head of the Cimini Lab in the Imaging Platform at the Broad Institute in Cambridge, MA. After doing undergraduate research in visual neuroscience with Dr. William Eldred at Boston University, she obtained a PhD in Biochemistry and Molecular Biology with Dr. Elizabeth Blackburn at UCSF, studying the difference between splicing variants of the telomere master scaffolding protein TIN2. These projects honed her interests in image analysis, leading her to join Dr. Anne Carpenter's lab at the Broad, where she led a team collaborating with approximately 30 outside scientists per year on their own custom image analysis projects. The Cimini lab focuses on bioimage analysis tool creation (Piximi) and maintenance (CellProfiler), as well as on applying open source tools to novel biological problems. She created and directs the Platform's Postdoctoral Training Program in Bioimage Analysis, and also leads the Broad efforts towards community engagement and driving biological projects for the Center for Open Bioimage Analysis (COBA).

To learn more about Dr. Cimini and her work, visit https://www.biorxiv.org/content/10.1101/2021.06.30.450416v3
and https://cimini-lab.broadinstitute.org/

Seminar Link: https://uconnvtc.webex.com/uconnvtc/j.php?MTID=mb1c84f4c06b4556296a6240cef05e821
Tuesday, Sep 28, 2021 3:00 pm | 1 hour 45 minutes | (UTC-04:00) Eastern Time (US & Canada)
Meeting number: 2620 331 1737
Password: MCB2021

Join by video system
Dial 26203311737@uconnvtc.webex.com
You can also dial 173.243.2.68 and enter your meeting number.

Spencer Nyholm
Dave Knecht

Pietro De Camilli, M.D.,
Departments of Neuroscience and of Cell Biology,
Howard Hughes Medical Institute,
Yale University School of Medicine,
Kavli Institute for Neuroscience,
New Haven, CT

Talk Title: "Novel pathways of intracellular membrane lipid transport and neurodegenerative diseases"

Host: Dr. Linnaea Ostroff

This particular session will cover how to develop and refine an effective research plan statement, one of the most important parts of your application. Attendees who have already worked with a faculty mentor to define the basics of their project idea will be positioned to get the most out of this session. You do not need to have attended the previous NSF GRFP application development sessions to benefit from this one.
For the most up to date information on ONSF upcoming events, please visit https://www.onsf.uconn.edu/.

About NSF - GRFP
The NSF Graduate Research Fellowship Program is a prestigious award that supports research-oriented students in a wide range of STEM and social science fields during their first three years of graduate school. The award includes a $34,000 stipend plus a $12,000 Cost of Education Allowance.

Eligibility
To be eligible, applicants must be either rising seniors or 1st year or 2nd year graduate students, plan on a PhD/research-oriented career, and be US Citizens or Permanent Residents. Eligible fields of study are: Chemistry, Computer and Information Science and Engineering, Engineering, Geosciences, Life Sciences, Materials Research, Mathematical Sciences, Physics and Astronomy, Psychology, Social Sciences, STEM Education and Learning Research.

Join from the meeting link
https://uconn-cmr.webex.com/uconn-cmr/j.php?MTID=m86594c4b05e6aad661dde2aa30f6b19a

Join by meeting number

Meeting number (access code): 2622 672 9248

Meeting password: iKJYMGmp267

This week in Cell Biology Journal Club, Michelle Antony will lead a discussion of “Targeting of EGFR by a combination of antibodies mediates unconventional EFGR trafficking and degradation” by Jones et al., 2020.

https://mcb.uconn.edu/wp-content/uploads/sites/2341/2021/09/Jones-et-al.pdf

Title: "The history and future of conservation"

See https://cese.uconn.edu/the-edwin-way-teale-lecture-series/

Katie Billmyre, NIGMS K99 Postdoctoral Fellow,
Stowers Institute for Medical Research, Kansas City

Host: Stacey Hanlon

Title: "Why do some chromosomes misbehave during meiosis?"

Summary: In Drosophila, partial-loss of function synaptonemal complex mutants exhibit different meiotic defects on the X chromosome versus the autosomes. Understanding how individual chromosome behavior is regulated is key to uncovering why chromosome-specific aneuploidies occur.

Bio:
Katie did her PhD in the lab of John Klingensmith at Duke where she focused on the signaling pathways necessary for the development of the mandible, the esophagus, and the trachea. She then did a short post-doc at UNC in the lab of Shawn Ahmed where she identified the first example of a meiotic gene promoting germ cell immortality. She currently is in the lab of Scott Hawley where she has been studying chromosome-specific differences during meiosis.

To learn more about Dr. Billmyre and her research, visit
https://www.pnas.org/content/116/43/21641.short
https://research.stowers.org/hawleylab/lab-members/katie-billmyre.html

Seminar can be live-streamed at https://www.kaltura.com/index.php/extwidget/preview/partner_id/2090521/uiconf_id/38934061/entry_id/1_904uedgo/embed/dynamic?

Title: TBD

Ashley Reed, Alder Lab

Irio Schiano, Heaslip Lab

MCB Faculty Meeting

https://uconn-cmr.webex.com/uconn-cmr/j.php?MTID=meab641d09f6121d1e9942aee19b4224b