We will hold an organizational meeting to discuss the format of the class and to sign up for leading journal article discussions over the semester.

This course can be taken for credit, or you can simply drop in for some lunchtime paper discussions. Please feel free to join us Thursday if you are interested in participating in CBJC this semester!

This week in Cell Biology Journal Club, the group will be discussing the following Review Article in preparation for related Research Article discussions in coming weeks. "Natural killer cells in antitumour adoptive cell immunotherapy" by Laskowski et al., 2022.

https://mcb.uconn.edu/wp-content/uploads/sites/2341/2022/09/Natural-Killer-Cells-in-Antitumor-Immunotherapy-Review.pdf

Don Stimpson

May Lab

"Elucidating the
Structure and Function of ALCAT1"

September Faculty Meeting

The first Microbiology Journal Club of the Fall 2022 semester

Kelly Crandall will present “A bacterium that degrades and assimilates poly(ethylene terephthalate)” by Yoshida et al. Science 2016 351:1196 https://www.science.org/doi/10.1126/science.aad6359, along with its accompanying technical comment https://www.science.org/doi/full/10.1126/science.aaf8305 and an author’s response https://www.science.org/doi/full/10.1126/science.aaf8625. There’s also an accompanying commentary as an easy entry point to the topic: https://www.science.org/doi/10.1126/science.aaf2853

Do you want $34,000? Would you like a prestigious honor on your CV? Are you a senior undergraduate thinking about graduate school or a 1st/2nd year graduate student in STEM or the social sciences? Are you a U.S. citizen, national resident, or permanent resident? If you answered yes to all these questions, then you should consider applying for the National Science Foundation’s Graduate Research Fellowship Program (NSF GRFP| https://www.nsfgrfp.org/).
The GRFP is one of the most preeminent honors that a young scholar can receive. In addition to the distinction, the GRFP provides research security and freedom by providing graduate students with $138,000 over three years. Simply put, as long as you meet the application’s criteria, there is no reason to pass up this opportunity. Learn more about who is eligible and what materials you need to apply by attending the NSF GRFP Fall application preparation series kickoff session: What is the GRFP? An Info Session. Besides covering the basics, we will walk you through all the steps of applying and answer any questions that you might have.

Meeting information:
Join from the meeting link
https://uconn-cmr.webex.com/uconn-cmr/j.php?MTID=m8497236945a72caf145bebecca5ecacd

Join by meeting number

Meeting number (access code): 2623 994 5413

Meeting password: n6uN6q6aQJE

This week's G&G journal club paper is "Site-specific MCM sumoylation prevents genome rearrangements by controlling origin-bound MCM" in PLoS Genetics. I've attached the article here along with a review on DNA replication licensing and initiation. It's a nice paper that illustrates the "awesome power of yeast genetics!"

https://mcb.uconn.edu/wp-content/uploads/sites/2341/2022/09/Costa_Annual-Review-of-Biochemistry_2022.pdf

https://mcb.uconn.edu/wp-content/uploads/sites/2341/2022/09/Quan_PLoS-Genetics_2022.pdf

As a reminder, this journal club is open to anyone who would like to attend. The discussion for each of the figures is led by a student enrolled in the course, so even if you haven't read the paper, feel free to come and learn. We meet in ESB 304 at 11:15am on Wednesdays.

Department of Molecular and Cell Biology
University of Connecticut


Announces the

Related Proposal for the Doctoral Degree

Jenn Podgorski


B.S./BA University of Connecticut


Evaluating the Role of Scaffolding Protein in Capsid Size Determination in "Wild" Bacteriophages

Thursday, September 15, 2022
12:00 PM
Webex
https://uconn-cmr.webex.com/uconn-cmr/j.php?MTID=mb4172f1c7dc4035f0e6655eca2219f50
Password (if needed): CpWm4kT9zD8


Major Advisor: Simon White
Associate Advisor: Carol Teschke
Associate Advisor: Eric May
Examiner: Peter Gogarten
Examiner: Victoria Robinson

This week in Cell Biology Journal Club, Colleen Brown will lead a discussion of "Primary CD33-targeting CAR-NK cells for the treatment of acute myeloid leukemia
” by Albinger et al., 2022.


https://mcb.uconn.edu/wp-content/uploads/sites/2341/2022/09/Albinger-et-al-2022.pdf

Title: "The effect of food subsidies on wildlife infectious disease"

The presentation will also be streamed via Kaltura. Contact host for details.

Katie Kyle

"Trachymyrmex septentrionalis ants promote fungus garden hygiene using Trichoderma-derived metabolite cues"

Klassen Lab

This week we will finish discussing "Site-specific MCM sumoylation prevents genome rearrangements by controlling origin-bound MCM"

https://mcb.uconn.edu/wp-content/uploads/sites/2341/2022/09/Costa_Annual-Review-of-Biochemistry_2022.pdf

https://mcb.uconn.edu/wp-content/uploads/sites/2341/2022/09/Quan_PLoS-Genetics_2022.pdf

As a reminder, this journal club is open to anyone who would like to attend. The discussion for each of the figures is led by a student enrolled in the course, so even if you haven't read the paper, feel free to come and learn. We meet in ESB 304 at 11:15am on Wednesdays.

Leonard Kaczmarek, PhD
Professor of Pharmacology and of Cellular And Molecular Physiology
Yale School of Medicine

Host: Dr. Tasso Tzingounis

This week in Cell Biology Journal Club, Heather Jamieson will lead a discussion of "A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy
” by Pomeroy et al., 2019.


https://mcb.uconn.edu/wp-content/uploads/sites/2341/2022/09/Pomeroy-et-al-2019.pdf

Title: Effects of draught on plant-insect interactions and reproduction

Hosted by UConn chapter of SEEDS (https://www.knutielab.com/uconn-seeds.html)

Dr. Recart González' web site: https://wrecart.wordpress.com

Dan Phillips will present “Phototrophy and carbon fixation in Chlorobi postdate the rise of oxygen” by Ward and Shih PLOS One 2022 17:e0270187.

https://mcb.uconn.edu/wp-content/uploads/sites/2341/2022/09/Ward_Shih_PLOS_ONE_2022.pdf

GO:MCB is hosting a coffee hour this Friday from 11-12 in BPB301. Come get some coffee and bagels before grad sem and socialize with your peers!

Alyssa Coulter

Campellone Lab

"Cell type-dependent functions for the actin cytoskeleton in proteostasis"

Jeremy Rotty, Ph.D.
Assistant Professor of Biochemistry and Molecular Biology
Uniformed Services University

Host: Ken Campellone

Join us at 3:15 in the BPB lobby for refreshments, Seminar begins at 3:30

"Context-dependent regulation of the actin cytoskeleton influences macrophage function”

Dr. Rotty obtained a Bachelor’s degree in biology from Berea College. He then completed his PhD in the lab of Dr. Pierre Coulombe at the Johns Hopkins School of Medicine. This work revealed a novel regulatory role for keratin intermediate filaments in Src kinase signaling and cell motility, which jumpstarted his career-long interest in cell migration and the cytoskeleton. Dr. Rotty then completed his postdoctoral training in Dr. James Bear’s lab at the University of North Carolina, Chapel Hill. His postdoctoral work revealed that the actin cytoskeleton is homeostatically regulated, and that the branched actin-polymerizing Arp2/3 complex is required for integrin-mediated extracellular sensing in macrophages. Since 2017, Dr. Rotty has been an assistant professor in the Department of Biochemistry at the Uniformed Services University where he continues to study cell migration, cytoskeletal regulation and extracellular matrix sensing.

To learn more about Dr Rotty and his research, view his publication at https://www.mdpi.com/2073-4409/11/11/1806 and visit his website at https://medschool.usuhs.edu/bio/research/rotty-lab

Livestream link: https://www.kaltura.com/index.php/extwidget/preview/partner_id/2090521/uiconf_id/38934061/entry_id/1_904uedgo/embed/dynamic?

"Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistance." Spoiler alert: they do a screen!

Paper and Commentary:
https://mcb.uconn.edu/wp-content/uploads/sites/2341/2022/09/Dolce_Genes-Development_2022.pdf

https://mcb.uconn.edu/wp-content/uploads/sites/2341/2022/09/Zhang_Genes-Development_2022_1.pdf

This particular session will cover how to develop and refine an effective research plan statement, one of the most important parts of your application. Attendees who have already worked with a faculty mentor to define the basics of their project idea will be positioned to get the most out of this session. You do not need to have attended the previous NSF GRFP application development sessions to benefit from this one. For the most up to date information on ONSF upcoming events, please visit https://www.onsf.uconn.edu/.

About NSF - GRFP The NSF Graduate Research Fellowship Program is a prestigious award that supports research-oriented students in a wide range of STEM and social science fields during their first three years of graduate school. The award includes a $34,000 stipend plus a $12,000 Cost of Education Allowance.

Eligibility To be eligible, applicants must be either rising seniors or 1st year or 2nd year graduate students, plan on a PhD/research-oriented career, and be US Citizens or Permanent Residents. Eligible fields of study are: Chemistry, Computer and Information Science and Engineering, Engineering, Geosciences, Life Sciences, Materials Research, Mathematical Sciences, Physics and Astronomy, Psychology, Social Sciences, STEM Education and Learning Research.

This session will be held online but if you are interested in attending an in-person session, one will be held on 9/29 at 11:30am in HBL Class of 1947.

Join from the meeting link
https://uconn-cmr.webex.com/uconn-cmr/j.php?MTID=ma0c3935a634878df9e1b2c46826326fb




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Meeting number (access code): 2621 702 4361

Meeting password: iKCeFwQK334



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Michelle Monette, PhD
Associate Professor of Physiology
Western Connecticut State University

Host: Dr. Jeffrey Divino