University of Connecticut
Department of Molecular & Cell Biology
91 North Eagleville Road, Unit 3125
Biology/Physics Building 248
Storrs, CT 06269-3125
Education: Postdoctoral Study, University of Michigan; Ph.D. University of Florida; B.S. Bucknell University
Research Interests: Our research lab works in the general area of computational and theoretical biophysics and biochemistry, with emphasis towards understanding conformational/phase transitions and the mechanical and thermodynamic properties of biological materials. These lines of research are intended to not only explain the underlying physical mechanisms in biology, but to also indentify principles that can be utilized in nanotechnology and biomedical applications. We are interested in informing and making strong connections to both single-molecule and ensemble averaged experimental measurements.
A major thrust in the lab is to understand how environmental stimuli can induce structural changes to non-enveloped viruses, which are critical in the infection process. Other areas of interest include membrane disruption/reconfiguration, protein folding and structural predictions, antibody design, and nanoparticle design.
Boyd, K.K., Alder, N.N., May, E.R. (2017) Buckling Under Pressure: Curvature Based Lipid Segregation and Stability Modulation in Cardiolipin Containing Bilayers. Langmuir , DOI: 10.1021/acs.langmuir.7b01185
Ward, M.D., Nangia, S., May, E.R.(2017) Evaluation of the hybrid resolution PACE model for the study of folding, insertion, and pore formation of membrane associated peptides. J. Comput. Chem., DOI: 10.1002/jcc.24694 .
J.G. Pattis, E.R. May (2016). Influence of RNA Binding on the Structure and Dynamics of the Lassa Virus Nucleoprotein, Biophys. J., 110(6):1246-1254.
A. Aggarwal, E.R. May, C.L. Brooks III, W.S. Klug (2016) Nonuniform elastic properties of macromolecules and effect of prestrain on their continuum nature, Phys. Rev. E 92, 012417.
Boyd, K.J., Bansal, P., Feng, J., May, E.R. (2015) Stability of Norwalk virus capsid protein interfaces evaluated by in-silico nanoindentation. Front. Bioeng. Biotechnol. 3:00103
Wowor, A.J., Yan, Y., Auclair, S.M., Yu, D., Zhang, J., May, E.R., Gross, M.L., Kendall, D.A. and Cole, J.L. (2014) Analysis of SecA Dimerization in Solution. Biochemistry, in press, DOI:10.1021/bi500348p
E.R. May (2014) Recent developments in molecular simulation approaches to study spherical virus
capsids, Molecular Simulation, DOI: 10.1080/08927022.2014.907899
E.R. May, C.L. Brooks III (2012) On the Morphology of Viral Capsids: Elastic Properties and Buckling Transitions, J. Phys. Chem. B 116:8604-8609.
E.R. May, J. Feng, C.L. Brooks III(2012) Exploring the Symmetry and Mechanism of Virus Capsid Maturation via an Ensemble of Pathways, Biophys. J. 102(3):606-612.
W.H. Roos, I. Gertsman, E.R. May, C.L. Brooks III, J.E. Johnson, G.J.L. Wuite (2012) The Mechanics of Bacteriophage Maturation, Proc. Natl. Acad. Sci. U.S.A. 109(7):2342-7.
E.R. May, A. Aggarwal, W.S. Klug, C.L. Brooks III (2011) Viral Capsid Equilibrium Dynamics Reveals Nonuniform Elastic Properties, Biophys. J. 100(11):L59-61.
E.R. May, C.L. Brooks III (2011) Determination of Viral Capsid Elastic Properties from Equilibrium Thermal Fluctuations, Phys. Rev. Lett. 106(18):188101.
E.R. May, R.S. Armen, A.M. Mannan, C.L. Brooks III (2010) The Flexible C-terminal Arm of the Lassa Arenavirus Z-Protein Mediates Interactions with Multiple Binding Partners, Proteins 78(10):2251-64.
E.R. May, D.I. Kopelevich, A. Narang, (2008) Coarse-Grained Molecular Dynamics Simulations of Phase Transitions in Mixed Lipid Systems Containing LPA, DOPA, and DOPE Lipids, Biophys. J. 94(3):878-90.
E.R. May, A. Narang, D.I. Kopelevich, (2007) Role of Molecular Tilt in Thermal Fluctuations of Lipid Membranes, Phys. Rev. E: Stat. Nonlin. Soft Matter Phys. 76(2 Pt 1):021913.