Andrei Alexandrescu
Professor
Molecular and Cell Biology / Structural Biology, Biochemistry and Biophysics (SB3)
Education: Ph.D. University of Wisconsin-Madison; Postdoctoral study, Oxford University; Johns Hopkins University Medical Institutes
Research Interests: High-resolution solution NMR of protein structure, folding, dynamics, and association; amyloids; phage/virus and pathogen proteins; unconventional zinc fingers; mitochondria; metabolomics.
Selected Publications:
[Click here to get nearly full publication list.]
Rua AJ, Mitchell W, Claypool SM, Alder NN, Alexandrescu AT, Perturbations in mitochondrial metabolism associated with defective cardiolipin biosynthesis: An in-organello real-time NMR study, Journal of Biological Chemistry (2024) https://doi.org/10.1016/j.jbc.2024.107746
Reed, A.L., Mitchell, W, Alexandrescu, A.T, Alder, N.N.. (2023) “Interactions of amyloidogenic proteins with mitochondrial protein import machinery in aging-related neurodegenerative diseases”, Front Physiol 14, 1263420 https://doi.org/10.3389/fphys.2023.1263420
Seo, D., Kammerer, R.A., & Alexandrescu, A.T. (2023) “Solution NMR assignments and structure for the dimeric kinesin neck domain”, Biomol NMR Assign, online ahead of print https://doi.org/10.1007/s12104-023-10159-x
Rua, A.J., Whitehead, R. 3rd, & Alexandrescu, A.T (2023) “NMR structure verifies the eponymous zinc finger domain of transcription factor ZNF750”, J Struct Biol X 8, article 100093.
https://doi.org/10.1016/j.yjsbx.2023.100093
Alexandrescu, A.T., Dregni, A.J. & Teschke, C.M. (2023) NMR detection and conformational dependence of two, three, and four-bond isotope shifts due to deuteration of backbone amides. J Biomol NMR 77, 93-109 (2023). https://doi.org/10.1007/s10858-023-00414-7
Wayne Mitchell, Jeffrey D Tamucci, Emery L Ng, Shaoyi Liu, Alexander V Birk, Hazel H Szeto, Eric R May, Andrei T Alexandrescu, Nathan N Alder (2022) Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds eLife 11:e75531 https://doi.org/10.7554/eLife.75531
Whitehead, R. D. III, Teschke, C.M., & Alexandrescu, A.T (2022) “Pulse-field gradient nuclear magnetic resonance of protein translational diffusion from native to non-native states”, Protein Sci, 31, e4321. https://doi.org/10.1002/pro.4321
Kaplan, A.R., Olson, R. &Alexandrescu, A.T (2021) “Protein yoga: conformational versatility of the hemolysin II C-terminal domain detailed by NMR structures for multiple states”, Protein Sci, 30, 990-1005. https://doi.org/10.1002/pro.4066
Dedeo, C.L., Teschke, C.M., & Alexandrescu, A.T(2020) “Keeping it together: structures, functions, and applications of viral decoration proteins”, Viruses 12, 1163. https://doi.org/10.3390/v12101163
Whitehead, R. D. III, Teschke, C.M., & Alexandrescu, A.T (2019) “NMR mapping of disordered segments for a viral scaffolding protein enclosed in a 23 MDa procapsid”, Biophysical J. 117: 1387-1392. DOI: 1016/j.bpj.2019.08.038
Newcomer, R.L., Schrad, J.R., Gilcrease, E.B., Casjens, S.R., Feig, M., Teschke, C.M., Alexandrescu, A.T, & Parent K.N. (2019) “The phage L capsid decoration protein has a novel OB-fold and an unusual capsid binding strategy”, eLife 8, e45345.https://doi.org/10.7554/eLife.45345
Tripler, T.N., Kaplan, A.R., Alexandrescu, A.T, & Teschke, C.M. (2019) “Conservation and divergence of the I-domain inserted into the ubiquitous HK97 coat protein fold in the P22-like bacteriophages”, Journal of Virology, 93: e0007-19. DOI: 10.1128/JVI.00007-19
| andrei.alexandrescu@uconn.edu | |
| Phone | 860-486-4414 |
| Fax | 860-486-4331 |
| Mailing Address | 91 North Eagleville Road, Unit 3125, Storrs, CT 06269-3125 |
| Office Location | Biology/Physics Building 209 |
| Link | http://ata.mcb.uconn.edu/ |