Andrei Alexandrescu
Professor
Molecular and Cell Biology / Structural Biology, Biochemistry and Biophysics (SB3)
Education: Ph.D. University of Wisconsin-Madison; Postdoctoral study, Oxford University; Johns Hopkins University Medical Institutes
Research Interests: High-resolution solution NMR of protein structure, folding, dynamics, and association; amyloids; phage/virus and pathogen proteins; unconventional zinc fingers; mitochondria; metabolomics.
Selected Publications:
[Click here to get nearly full publication list.]
Woodbury BM, Newcomer RL, Leroux MN, Alexandrescu AT, Teschke CM. Templated trimerization of the phage L decoration protein on capsids. Protein Sci. 2025 Apr;34(4):e70089. doi: 10.1002/pro.70089. PMID: 40100157.
Harris, R. E, Whitehead, R. D. 3d, Alexandrescu, A.T. (2025) “Solution structure of the Z0 domain from transcription repressor BCL11A sheds light on the sequence properties of protein-binding zinc fingers”, Protein Science 34, e70097. http://dx.doi.org/10.1002/pro.70097
Rua AJ, Mitchell W, Claypool SM, Alder NN, Alexandrescu AT, Perturbations in mitochondrial metabolism associated with defective cardiolipin biosynthesis: An in-organello real-time NMR study, Journal of Biological Chemistry (2024) https://doi.org/10.1016/j.jbc.2024.107746
Reed, A.L., Mitchell, W, Alexandrescu, A.T, Alder, N.N.. (2023) “Interactions of amyloidogenic proteins with mitochondrial protein import machinery in aging-related neurodegenerative diseases”, Front Physiol 14, 1263420 https://doi.org/10.3389/fphys.2023.1263420
Seo, D., Kammerer, R.A., & Alexandrescu, A.T. (2023) “Solution NMR assignments and structure for the dimeric kinesin neck domain”, Biomol NMR Assign, online ahead of print https://doi.org/10.1007/s12104-023-10159-x
Rua, A.J., Whitehead, R. 3rd, & Alexandrescu, A.T (2023) “NMR structure verifies the eponymous zinc finger domain of transcription factor ZNF750”, J Struct Biol X 8, article 100093.
https://doi.org/10.1016/j.yjsbx.2023.100093
Alexandrescu, A.T., Dregni, A.J. & Teschke, C.M. (2023) NMR detection and conformational dependence of two, three, and four-bond isotope shifts due to deuteration of backbone amides. J Biomol NMR 77, 93-109 (2023). https://doi.org/10.1007/s10858-023-00414-7
Wayne Mitchell, Jeffrey D Tamucci, Emery L Ng, Shaoyi Liu, Alexander V Birk, Hazel H Szeto, Eric R May, Andrei T Alexandrescu, Nathan N Alder (2022) Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds eLife 11:e75531 https://doi.org/10.7554/eLife.75531
Whitehead, R. D. III, Teschke, C.M., & Alexandrescu, A.T (2022) “Pulse-field gradient nuclear magnetic resonance of protein translational diffusion from native to non-native states”, Protein Sci, 31, e4321. https://doi.org/10.1002/pro.4321
Kaplan, A.R., Olson, R. &Alexandrescu, A.T (2021) “Protein yoga: conformational versatility of the hemolysin II C-terminal domain detailed by NMR structures for multiple states”, Protein Sci, 30, 990-1005. https://doi.org/10.1002/pro.4066
Dedeo, C.L., Teschke, C.M., & Alexandrescu, A.T(2020) “Keeping it together: structures, functions, and applications of viral decoration proteins”, Viruses 12, 1163. https://doi.org/10.3390/v12101163
| andrei.alexandrescu@uconn.edu | |
| Phone | 860-486-4414 |
| Fax | 860-486-4331 |
| Mailing Address | 91 North Eagleville Road, Unit 3125, Storrs, CT 06269-3125 |
| Office Location | Biology/Physics Building 209 |
| Link | http://ata.mcb.uconn.edu/ |