2024 MCB Department Retreat

September 5, 2024

2024 MCB Department Retreat

The Annual MCB Department Retreat was held on 8/22/24 at the beautiful UConn Avery Point campus. Highlights include the presentation of MCB Summer Fellowship Awards, Research talks by new faculty members Dylan Murray and Kristen Ramsey, a Poster Session, food trucks, a lively trivia game, and announcement of the first annual MCB image competition winners.

See photos of the event!

MCB Department Welcomes New Faculty

September 3, 2024

MCB is excited to introduce our two newest faculty members, Dylan Murray and Kristin Ramsey.

Dylan MurrayDylan Murray joins the Department of Molecular and Cell Biology as an assistant professor. Murray earned his doctorate degree in molecular biophysics from Florida State University and worked as a postdoctoral fellow at the National Institutes of Health. Murray’s research interest focuses on how microscopic molecules like proteins and DNA in humans and plants collectively produce much larger phenomena required to maintain life. His work has broad applications from fighting neurodegenerative disease and cancer to engineering plants to produce petrochemicals or to survive drought.
Read more about Dr. Murray -
A Cool Spin on Large Biomolecular Complexes

 

Kristen RamseyKristen Ramsey joins the Department of Molecular and Cell Biology as an assistant professor. She received her bachelor’s degree in biochemistry from Florida State University as a Goldwater Scholar and her doctoral degree at the University of California, San Diego in the Department of Chemistry and Biochemistry. Ramsey previously served as an NIH Postdoctoral Fellow in the Department of Biophysics at Johns Hopkins University. Her research is focused on integrating molecular biophysical approaches with cell-based functional assays to further understand the fundamental biology of pathogen-sensing and signaling by innate immune RNA sensors from humans, birds, and scavenger species.

MCB and ISG Introduce New Geroscience Research Program

August 21, 2024

We’re all getting older. But more Americans are old now than ever before—and that’s both a strain on the medical system and a scientific opportunity. University of Connecticut undergraduates can now study the biology of aging through a new program offered by the Institute for Systems Genomics and Department of Molecular & Cell Biology. See full article in UConn Today

MCB Announces 2023-2024 Outstanding TA Awards

August 12, 2024

Corey Theodore and Richard Whitehead have been named the 2023-2024 Outstanding MCB TAs in recognition of their outstanding contributions, professional dedication to inspiring student learning and commitment to education. Please join us in congratulating Corey and Richard on their notable accomplishments!

2023-2024 Professional Science Master’s Program Report

August 9, 2024

Author: Christine Ricci, PSM Manager

Organization

The Professional Science Master’s programs have been undergoing some changes over the past fiscal year.

Two new appointments in the administration of the PSM programs have been made.  First, Dr. Spencer Nyholm began as the new Director of the Applied Microbial Systems Analysis program.  Second, Christine Ricci is the new PSM Program Manager.

A small quiet study room was created in the Torrey Life Sciences Building within the PSM wing on the fourth floor specifically for PSM students use.  Future improvements include updating the general Microbial and Cell Biology graduate student lounge, also located on the fourth floor of the Torrey Life Sciences building.

Courses and Modules

PSM Modules continue to be popular and relevant to PSM students and other graduate students.  Some of the popular courses continue to be MCB 5427 Laboratory Techniques in Functional Genomics (all topics), MCB 5895 Introduction to the Theory and Practice of Flow Cytometry, MCB 5895 Introduction to R and R Studio, MCB 5895 Protein Purification, and MCB 5672 Advanced Theory and Practice of Laboratory Techniques in Microbiology: Advanced Liquid Handling and Sample Processing.

Internships Summer 2023

The PSM programs continue to have students intern at a variety of institutions.  Four students interned over Summer 2023.  Organizations included Weill Cornell in New York City, Torigen Pharmaceuticals, the Graf lab at UConn, and a six-month co-op at Merck.

Graduates

The PSM program congratulates five recent graduates!  Tejaswinee Kota (Applied Genomics) and Michael Piekarsky (Applied Biochemistry and Cell Biology) both graduated in December 2023.  Paige Ansich (Applied Biochemistry and Cell Biology) and Emily Karovic (Microbial Systems Analysis) graduated this past May and Yucheng Zhang and Rich Green will both finish this August. We are looking forward to following their careers!

PSM Professional Seminar Speakers:

Twenty-four speakers presented at the PSM Professional Seminar over 21 weeks, including seven PSM alums.  Speakers represented a range of professions from academia, industry, and government as well as various career stages from early (first job) through mid-career, and even retired.

Marketing

The PSM team initiated a strategic marketing plan to increase program awareness, attract new applicants, and most importantly foster a tight student and alumni community.  As part of this effort, a LinkedIn Page and Group were initiated in Spring 2024 to network with alumni, potential speakers, and potential students.  To showcase our ever-improving PSM space, a 4’ x 6’ banner was designed and hung on the fourth floor of the Torrey Life Sciences building to welcome students and guests.

In mid-April the PSM team hosted a booth at UConn’s Student Union to meet and engage with UConn undergraduates.  Interested students were from all academic years (first-years through graduating seniors). A number of outreach activities including attending graduate student fairs and open houses are planned for the 2024/2025 academic year.

Additionally, the PSM website was redesigned with many updates, new (or additional) content, graphics (including the updated PSM logo), and layout.  This new webpage will feature sections specifically designed for new and current students; notable alumni; and potential industrial, governmental, or academic collaborations.  If you’re interested in being a featured alumnus or collaborating with the PSM programs, please reach out to Christine Ricci at chr06004@uconn.edu.

Alumni

The PSM programs are actively reaching out and connecting with alumni.  If you are an alumnus looking to connect back with the PSM programs, please find us on LinkedIn and/or reach out to Christine Ricci at chr06004@uconn.edu.

Conclusions

Many changes have been happening in the PSM programs, from personnel changes to marketing strategies.  The PSM programs continue to train high quality students into the growing biotech workforce.  As our network strengthens, we hope to continue to improve and expand the programs

Virginia Lyle King Wins Paper-of-the-Year in Molecular Biology of the Cell

August 5, 2024

Molecular Biology of the Cell (MBoC) has named Virginia Lyle King as a winner of the 2024 MBOC Paper of the Year Award for her research paper, F-actin–rich territories coordinate apoptosome assembly and caspase activation during DNA damage–induced intrinsic apoptosis. Awarded to the first author on a paper (grad student or postcoc), King was chosen by the Editorial Board of ASCB's science research journal, MBoC, as one of the best papers published from June of the previous year to May.

Dr. King (Virginia Lyle) received her Ph.D. in Molecular and Cell Biology at the University of Connecticut in the laboratory of Dr. Ken Campellone, and her B.S. in Biology at the University of Mary Washington.

Dr. King is an Associate of Cure Ventures with over 10 years of research experience. As a member of the Cure Ventures team, Lyle is involved in sourcing new deals, conducting due diligence, and assisting with company creation endeavors.

Most recently, she worked at the University of Connecticut as a graduate researcher where she gained extensive experience utilizing a broad range of genetic and molecular biology tools to study the spatiotemporal regulation of cellular stress responses in relation to human diseases, with a specific interest in cell death and cancer biology research. Her work established the actin cytoskeleton and actin-binding proteins as essential regulators of cell death and identified the importance of actin in coordinating the progression of apoptosis pathways. These discoveries bridged a longstanding gap between the cytoskeleton and apoptosis fields and provided new avenues for studying tumorigenesis. In addition to her academic research, Lyle cultivated effective leadership experience by mentoring junior scientists, teaching multiple courses in both laboratory and classroom settings, and volunteering for nonprofit educational programs that work to address the communication gap that exists between the general public and scientific communities.

Congratulations Dr. King!

MCB Undergraduate Student Success

July 15, 2024

MCB Graduate Stephanie Schofield, (’23 CLAS), Among Ten UConn Fulbright Recipients for 2023-24


2024 SURF Awards

Keertana Chagari ’25 (Molecular and Cell Biology, CLAS) Project Title: Reproducible Bioinformatic Workflows to Produce Diploid Phased Eukaryotic Genome Assemblies Faculty Mentor: Dr. Jill Wegrzyn, Ecology and Evolutionary Biology

Peter Fatzinger ’26 (Molecular and Cell Biology, CLAS) Project Title: Dynamic Changes in Chromosome Territories During Early Drosophila Embryogenesis Faculty Mentor: Dr. Jelena Erceg, Molecular and Cell Biology

Ryan Frier ’25 (Molecular and Cell Biology & Statistics, CLAS) Project Title: Investigating the Role of Actin Nucleation Factors in Mitosis Faculty Mentor: Dr. Kenneth Campellone, Molecular and Cell Biology

Suheera Haq ’26 (Molecular and Cell Biology & Individualized Major, CLAS) Project Title: Assessing the Role of BRD4 in Chlorine-Induced Lung Injury and Inflammation Faculty Mentor: Dr. Ley Smith, Pharmaceutical Sciences

Anthony He ’26 (Molecular and Cell Biology, CLAS) Project Title: Assembly and Annotation of a Chromosome-Scale Reference Genome for the Golden Conure (Guaruba guarouba) Faculty Mentor: Dr. Jill Wegrzyn, Ecology and Evolutionary Biology

Emmanuel Hernandez ’25 (Molecular and Cell Biology & Physiology and Neurobiology, CLAS) Project Title: How The Effects of a Forest Fire Change Ant and Fungus Microbiomes Faculty Mentor: Dr. Jonathan Klassen, Molecular and Cell Biology

Ruiwen Lin ’25 (Molecular and Cell Biology & Ecology and Evolutionary Biology, CLAS) Project Title: Exploring Hybridization in Lungless Salamanders Faculty Mentor: Dr. Hunmin Jung, Pharmaceutical Sciences

Nora Lippai ’26 (Molecular and Cell Biology, CLAS) Project Title: Viral-Induced Readthrough Transcription: Characterizing Viral Tactics to Impede Transcription Termination Faculty Mentor: Dr. Leighton Core, Molecular and Cell Biology

Kira O’Brien, Dec. ’24 (Molecular and Cell Biology, CLAS) Project Title: Investigating Bacterial Glycan Utilization in the Reproductive Organ of Euprymna scolopes Using Metagenomic and Cell Culture Approaches Faculty Mentor: Dr. Spencer Nyholm, Molecular and Cell Biology

Bianca Planeta ’25 (Molecular and Cell Biology, CLAS) Project Title: Investigating the Role of ORF1 in the Transposition of the Centromere-Enriched Retroelement G2/Jockey-3 Faculty Mentor: Dr. Barbara Mellone, Molecular and Cell Biology

Arianna Roach ’25 (Molecular and Cell Biology, CLAS) Project Title: Exploring Transgenerational Epigenetic Inheritance: Examining Loss of Imprint in F1 Hybrid Female Mice Due to X Chromosome Epimutation Faculty Mentor: Dr. Rachel O’Neill, Molecular and Cell Biology

Annette St. Jacques ’26 (Molecular and Cell Biology, CLAS) Project Title: The Effect of Maternal Age on B Chromosome Transmission in Drosophila melanogaster Faculty Mentor: Dr. Stacey Hanlon, Molecular and Cell Biology

Victoria Yi ’25 (Molecular and Cell Biology, CLAS) Project Title: The Basic Structure of Myosin F Needed for Intracellular Survival of Toxoplasma Gondii Faculty Mentor: Dr. Aoife Heaslip, Molecular and Cell Biology


MCB Major Paxton Tomko Receives National Science Foundation Graduate Research Fellowship

Paxton Tomko ’24 (CLAS) is a molecular and cell biology major and her faculty mentor is Assistant Professor of Molecular and Cell Biology/Microbiology Geo Santiago-Martínez. In the fall, she will be starting a master’s in oceanography at UConn Avery Point, working with Professor of Marine Sciences Pieter Visscher. Tomko’s research interests are in geobiology and astrobiology and is interested in stromatolites as biosignatures and the role that methanogens play in microbial mats.


MCB Students Win Undergraduate Research Symposium Awards

The All-Biology Colloquium was held with great success on Friday, April 26, 2024. The Colloquium showcased undergraduate research occurring in the three Biology departments at UConn. The panel of judges selected three MCB undergraduates to receive an award. Sindy Gorka received the Excellence in Applied Genetics award, Olivia Bowes received the Margaret Ertman Award, and Emma Beard received the Outstanding Senior in MCB award.


2023 Drotch Memorial Scholarship

Structural Biology/Biophysics student Youn Joong Kim was awarded a 2023 Drotch Memorial Scholarship. This competition is open to UConn undergraduates in biology, including Biological Sciences, EEB, MCB, PNB, and Biophysics, who have demonstrated both scholarship and financial need and who have completed a minimum of 3 and a maximum of 7 semesters of study.


2024 University Scholars

Fraser McGurk, Investigating the Role of CD13 in Macrophage-to-Myofibroblast Transition During Implant-Induced Foreign Body Reaction

Nazanin Zaer, Investigating the Healthcare Barriers Impacting Immigrant Women in Connecticut Clinics


 

2023-2024 MCB Graduate Student Awards

Fall 2023 MCB Graduate Travel Award

Josette Nammour received the Fall award in recognition of their outstanding graduate seminar. This bi-annual award provides support to students for conference attendance to enrich their graduate program study and is offered on a competitive basis to the most highly qualified student.


2024 MCB Summer Fellowship Awards

Claire M. Berg Graduate Fellowship in Genetics – Danielle Arsenault,  Katelyn DeNegre, Samantha Peterson

Arthur Chovnick Graduate Fellowship in Genetics – Michelle Neitzey 

Richard C. Crain, Jr. Memorial Fellowship – Ashley Reed, Richard Whitehead

Cross-Disciplinary Fellowship in MCB and Pharmaceutical Sciences – Michael Griffith

Dr. Edward A. and Dr. Lamia H. Khairallah Graduate Fellowship – Josette Nammour (MCB), Michael Samulevich (Pharm), Aniket Wahane (Pharm), Hangyu (Isabella), Wu (Pharm)

Jean Lucas-Lenard Special Summer Fellowship in Molecular Cell Biology – Trevor Hunter

Jean Lucas-Lenard Special Summer Fellowship in Biochemistry – Camille Pearce, Morgan Wagner

Philip I. Marcus Graduate Student Fellowship in Virology – Ian Barron

Pfizer Summer Fellowship in Molecular and Cell Biology – Alyssa Coulter, Daniel Phillips, Kaylah Samuelson

Antonio H. & Marjorie J. Romano Graduate Education Fellowship – Sarah Pasqualetti, Caroline Vieira Da Silva

Todd M. Schuster Award in Molecular and Cell Biology – Jolie Atwood, Ryan Frier

Biohaven Pharmaceuticals Fellowship – Giancarlo Montovano, Nadine Lebek, Sophia Gosselin, Jacob Kellermeier

Learn more about these fellowships


2023/2024 Outstanding TA Awards

Corey Theodore and Richard Whitehead


2024 Summer Doctoral Dissertation Fellowship Awards

Alyssa Coulter, Ryan Drennan, Jacob Kellermeier, Nadine Lebek, Michelle Neitzey


Conference Participation Award

Fall 2023
Alyssa Coulter, Katelyn DeNegre, Yutian Feng, Daniel Phillips

Spring 2024
John Briseno, Nadine Lebek, Michelle Neitzey


DEMI Awards

Fall 2023
Michael Griffith, Derrick Kamp

Spring 2024
Katelyn DeNegre, EmilyFuller, Jeffrey Tamucci, Nidhi Vijayan

 

First-Ever Sequencing of Great Ape X and Y Chromosomes

June 18, 2024

UConn researchers helped complete nationwide effort to understand ape genome. Tor the first time, researchers have assembled a complete “end-to-end” reference genome for the sex chromosomes of five great ape species and one lesser ape species. The findings shed light on the evolution of sex chromosomes and inform understanding of diseases related to genes on these chromosomes in both apes and humans. Read full story in UConn Today