Philip Yeagle

Professor Emeritus

Molecular and Cell Biology

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Retired: 2007

Currently: Adjunct Faculty, Faculty Prizes and Awards Coordinator

Education: B.A. St. Olaf College, Ph.D. Duke University, Postdoc, University of Virginia

Research Interests: Critical problems of membrane protein structure.

Selected Publications:

“Cell Membrane Specializations”, P.L. Yeagle, Encyclopedia of Life Sciences, Wiley, London, in press

“Lipids,” P.L. Yeagle, In: eLS. John Wiley & Sons, Ltd: Chichester (2014) http://www.els.net/ [DOI: 10.1002/9780470015902.a0000711.pub3]

“Non-covalent binding of membrane lipids to membrane proteins,” Philip Yeagle, Biochemica et Biophysica Acta Biomembranes, 1838, 1548–1559 (2014). [10.1016/j.bbamem.2013.11.009]

“Aggregatibacter actinomycetemcomitans leukotoxin cytotoxicity occurs through bilayer destabilization”, AC Brown, K Boesze-Battaglia, Y Du, FP Stefano, IR Kieba, RF Epand, L Kakalis, PL Yeagle, RM Epand, ET Lally, Cell Microbiol. 14, 869-891 (2012).

“Toward 3D structure of membrane proteins from peptide fragments”, Arlene D. Albert & Philip L.Yeagle, Methods in Molecular Biology, 654, 283-303, Humana Press (2010).

“Cell Membrane Specializations”, P.L. Yeagle, Encyclopedia of Life Sciences, Wiley, London (2010).

“Lipids”, P.L. Yeagle, In: ENCYCLOPEDIA OF LIFE SCIENCES. John Wiley & Sons, Ltd: Chichester http://www.els.net/[DOI: 10.1002/9780470015902.a0000711.pub2] (2009).

“A Small Subset of Signal Peptidase Residues are Perturbed by Signal Peptide Binding”, Monika Musial-Siwek,Philip L. Yeagle,& Debra A. Kendall, Chem. Biol. & Drug Design, 72, 140-146 (2008).

“Solution NMR of signal peptidase, a membrane protein,”M Musial-Siwek, DA Kendall, and PL Yeagle, Biochim Biophys Acta,  1778, 937-44 (2008).

“Three dimensional structures of GPCRs”, Arlene D. Albert and Philip L. Yeagle Biochim. Biophys.Acta, 1768, 808-824 (2007).

“Transmembrane helices may flex to satisfy hydrophobic mismatch,” Michael Bennett, Vincent Lemaître, Anthony Watts and Philip L. Yeagle, Biochim. Biophys. Acta,1768, 530-537 (2007).

“The tetraspannin protein, peripherin-2, complexes with melanoregulin, a putative membrane fusion regulator”, Kathleen Boesze-Battaglia, Lisa Pankoski-Walker, Cheryl Gretzula, Linda Otis, Bridget Gallagher, Rivka A. Rachel, Nancy A. Jenkins, Neal G. Copeland, Francine Morris, Philip Yeagle and Monika Damek-Poprawa, Biochemistry,46 1256 – 1272 (2007).

“Peripherin-2: an intracellular analogy to viral fusion proteins”, T. Edrington, R. Lapointe, P.L. Yeagle, Cheryl L. Gretzula, and K. Boesze-Battaglia, Biochemistry, 46 3605-3613 (2007).

“Calcium dependent association of calmodulin with the C-terminal domain of the tetraspannin protein peripherin/rds”, T.C. Edrington V, P.L. Yeagle, Cheryl L. Gretzula, and K. Boesze-Battaglia, Biochemistry, 46, 3862-3871 (2007).

“Differential stability among the transmembrane helices of lactose permease may be important to transport”, Michael Bennett, Robert d’Rozario, Mark Sansom and Philip L. Yeagle, Biochemistry, 45, 8088-8095 (2006).

“Insight into membrane protein structure from high resolution NMR”, Modern Magnetic Resonance, Graham A. Webb, ed. Springer, p331-339 (2006).

“Molecular Dynamic Simulations Of Retinal In Rhodopsin: From The Dark-Adapted State Towards Lumirhodopsin,” Vincent Lemaître, Philip L.Yeagle, & Anthony Watts, Biochemistry44, 12667-80(2005).

“Structural studies of the putative helix 8 in the human β2 adrenergic receptor: an NMR study”, M. Katragadda, M.W. Maciejewski, and P.L. Yeagle, Biochim. Biophys. Acta, 1663, 74-81, (2004).

“Stability of loops in the structure of lactose permease”, Michael Bennett, James A. Yeagle, Mark Maciejewski, James Ocampo, and P. L. Yeagle, Biochemistry, 43, 12829-12837, (2004).

“A conformational trigger for the activation of a G protein by a G protein coupled receptor”, Philip L. Yeagle and Arlene D. Albert, Biochemistry, 42, 1365-1368 (2003).

“Structural studies of Metarhodopsin II, the activated form of the G-protein coupled receptor, rhodopsin”, Gregory Choi, Judith Landin, Jhenny Flor Galan, Robert R. Birge, Arlene D. Albert and Philip L. Yeagle, Biochemistry, 41, 7318-7324 (2002).

“Use of NMR to study the three dimensional structure of rhodopsin, A. D. Albert and P. L. Yeagle, Methods in Enzymology, v343, 223-231 (2002).

“Structural studies on rhodopsin”, Arlene D. Albert and Philip L. Yeagle, Biochim. Biophys. Acta.1565,183-195 (2002).

“Structures of the Transmembrane Helices of the G-protein Coupled Receptor, Rhodopsin”, Madan Katragadda, Atin Chopra, Michael Bennett, James L. Alderfer, Philip L. Yeagle and Arlene D. Albert, J. Peptide Res., 58: 79-89 (2001).

“Assembly of a polytopic membrane protein structure from the solution structures of overlapping peptide fragments of bacteriorhodopsin”, Madan Katragadda, James L. Alderfer and Philip L. Yeagle, Biophys. J. 81: 1029-1036 (2001).

“Studies on the structure of the G-protein coupled receptor rhodopsin including the putative G-protein binding site in unactivated and activated forms”, Philip L. Yeagle, Gregory Choi, and Arlene D. Albert, Biochemistry, 40, 11932-11937 (2001).

Selected Books:

Reference book, entitled “Structure of Biological Membranes, 2^nd edition”, P.L. Yeagle, (editor), CRC Press, Boca Raton, 2004 (ISBN 0-8493-1403-8).

Reference book, entitled “Structure of Biological Membranes, 3^rd edition”, P.L. Yeagle, (editor), CRC Press, Boca Raton, 2012 (ISBN 9781439809570).

Textbook, entitled “The Membranes of Cells, 3^rd edition, under contract with Academic Press, P.L. Yeagle (sole author).

Essays:

On hindsight and gratitude, Philip Yeagle, ASBMB Today, 13, p18 (2014)

Blogs:

http://www.huffingtonpost.com/dr-philip-l-yeagle/public-universities-tuition_b_2234314.html

http://www.huffingtonpost.com/dr-philip-l-yeagle/federal-college-ratings_b_3948253.html