Nichole Broderick
Assistant Professor, Gratis Appointment
Molecular and Cell Biology / Microbiology
Education: PhD, University of Wisconsin; Postdoc, EPFL, Switzerland
Research Interests: The goal of my laboratory is to address fundamental questions related to animal biology by understanding the mechanisms that underlie animal-microbiome interactions. We use Drosophila melanogaster and its associated microbiota to study the impacts of beneficial and pathogenic bacteria on host development, physiology, and health using a variety of molecular, genetic, and genomic approaches.
Selected Publications:
Fischer C, Trautman E, Crawford J, Stabb E, Handelsman Jo, Broderick N. (2017) Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior. eLife 6:e18855.
Benoit J, Vigneron A, Broderick N, Wu Y, Sun J, Carlson J, Aksoy S, Weiss B. (2017) Symbiont-induced odorant binding proteins mediate insect host hematopoiesis. eLife 6: e19535.
Stulberg E, GL Lozano, JB Morin, H Park, EG Baraban, C Mlot, C Heffelfinger, GM Phillips, JS Rush, AJ Phillips, NA Broderick, MG Thomas, EV Stabb, J. Handelsman. 2016. Genomic and secondary metabolite analyses of Streptomyces sp. 2AW provide insight into the evolution of the cycloheximide pathway. Front Microbiol 7:573
Broderick, NA 2016. Friend, foe or food? Recognition and the role of antimicrobial peptides in gut immunity and Drosophila–microbe interactions. Phil Trans R Soc. B 371:20150295
Broderick, N. A. 2015. A common origin for digestion and immunity. Front Immunol 6:72
Broderick, N. A., N. Buchon, and B. Lemaitre. 2014. Microbiota-induced changes in Drosophila melanogaster gene expression and gut morphology. mBio 5(3):e01117-14.
Buchon, N.*, N. A. Broderick*, and B. Lemaitre. 2013. Gut homeostasis in a microbial world: insights from Drosophila melanogaster. Nature Rev Microbiol 11: 615–626.
Broderick, N. A. and B. Lemaitre. Gut associated bacteria of Drosophila. 2012. Gut Microbes 3: 307-321.
Buchon, N.*, N. A. Broderick*, T. Kuraishi, and B. Lemaitre. 2010. Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. BMC Biol 22:152.
Buchon, N., N. A. Broderick, S. Chakrabarti, and B. Lemaitre. 2009. Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev 23:2333-2344.
Buchon, N., N. A. Broderick, M. Poidevin, S. Pradervand, and B. Lemaitre. 2009. Drosophila Intestinal Response to Bacterial Infection: Activation of Host Defense and Stem Cell Proliferation. Cell Host Microbe 5: 200-211.
Broderick, N. A., C. J. Robinson, M. D. McMahon, J. Holt, J. Handelsman, and K. F. Raffa. 2009. Contributions of gut bacteria to Bacillus thuringiensis induced mortality vary across a range of Lepidoptera. BMC Biol 7:11.
Broderick, N. A., K. F. Raffa, and J. Handelsman. 2006. Midgut bacteria required for Bacillus thuringiensis insecticidal activity. Proc Natl Acad Sci USA. 103: 15196-15199.
Broderick, N. A., K. F. Raffa, R. M. Goodman, and J. Handelsman. 2004. Census of the bacterial community of the gypsy moth larval midgut using culturing and culture-independent methods. Appl Environ Microbiol. 70: 293-300.
Broderick, N.A., R. M. Goodman, K. F. Raffa, and J. Handelsman. 2000. Synergy between zwittermicin A and Bacillus thuringiensis subsp. kurstaki against gypsy moth (Lepidoptera: Lymantriidae). Environ Entomol 29:101-107.
*denotes equal contribution
