Michael Lynes

Professor

Molecular and Cell Biology / Cell and Developmental Biology / Genetics and Genomics

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Education: Ph.D. University of North Carolina

Research Interests: Genetic and biochemical regulation of lymphocyte activation and differentiation in normal and stressed immune responses. Role of environmental toxicants in diseases of the immune system, and metallothionein-mediated mechanisms of immunotoxicity. Mechanisms of chemotactic cell movement.  Multiplexed microarray platforms for cell and protein detection.

Selected Publications:

Maltz-Matyschsyk M, Melchiorre CK,Knecht DA, Lynes MA.0.Bacterial metallothionein, PmtA, a novel stress protein found on the bacterial surface of Pseudomonas aeruginosa and involved in management of oxidative stress and phagocytosis. mSphere0:e00210-24 .https://doi.org/10.1128/msphere.00210-24

Clare K. Melchiorre, Matthew D. Lynes, Sadikshya Bhandari, Sheng-Chiang Su, Christian M. Potts, Amy V. Thees, Carol E. Norris, Lucy Liaw, Yu-Hua Tseng and Michael A. Lynes, Extracellular metallothionein as a therapeutic target in the early progression of Type 1 Diabetes, Cell Stress and Chaperones, (2024) https://doi.org/10.1016/j.cstres.2024.03.005

Mayer MP, Blair L, Blatch GL, Borges TJ, Chadli A, Chiosis G, de Thonel A, Dinkova-Kostova A, Ecroyd H, Edkins AL, Eguchi T, Fleshner M, Foley KP, Fragkostefanakis S, Gestwicki J, Goloubinoff P, Heritz JA, Heske CM, Hibshman JD, Joutsen J, Li W, Lynes M, Mendillo ML, Mivechi N, Mokoena F, Okusha Y, Prahlad V, Repasky E, Sannino S, Scalia F, Shalgi R, Sistonen L, Sontag E, van Oosten-Hawle P, Vihervaara A, Wickramaratne A, Wang SXY, Zininga T. Stress biology: Complexity and multifariousness in health and disease. Cell Stress Chaperones. 2024 Feb;29(1):143-157. doi: 10.1016/j.cstres.2024.01.006. Epub 2024 Feb 3. PMID: 38311120; PMCID: PMC10939078.

Maltz-Matyschsyk M, Melchiorre CK, Herbst KW, Hogan AH, Dibble K, O’Sullivan B, Graf J, Jadhav A, Lawrence DA, Lee WT, Carson KJ, Radolf JD, Salazar JC, Lynes MA; Connecticut Children’s COVID Collaborative. Development of a biomarker signature using grating-coupled fluorescence plasmonic microarray for diagnosis of MIS-C. Front Bioeng Biotechnol. 2023 Mar 31;11:1066391. doi: 10.3389/fbioe.2023.1066391. PMID: 37064248; PMCID: PMC10102909.

Devisscher L, Van Campenhout S, Lefere S, Raevens S, Tilleman L, Van Nieuwerburgh F, Van Eeckhoutte HP, Hoorens A, Lynes MA, Geerts A, Laukens D, Van Vlierberghe H. (2022) Metallothioneins alter macrophage phenotype and represent novel therapeutic targets for acetaminophen-induced liver injury. J Leukoc Biol. 111(1):123-133. https://doi.org/10.1002/JLB.3A0820-527R

Thees AV, Pietrosimone KM, Melchiorre CK, Marden JN, Graf J, Lynes MA, Maltz-Matyschsyk M. PmtA Regulates Pyocyanin Expression and Biofilm Formation in Pseudomonas aeruginosa. Front Microbiol. 2021 Nov 15;12:789765. doi: 10.3389/fmicb.2021.789765. PMID: 34867928; PMCID: PMC8636135.

Riedelberger M, Penninger P, Tscherner M, Hadriga B, Brunnhofer C, Jenull S, Stoiber A, Bourgeois C, Petryshyn A, Glaser W, Limbeck A, Lynes MA, Schabbauer G, Weiss G, Kuchler K. Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion. iScience. 2020 May 22;23(5):101121. doi: 10.1016/j.isci.2020.101121. Epub 2020 May 4. PMID: 32428860; PMCID: PMC7232100.

Bhandari, S., and M.A. Lynes (2019) Analysis of toxin- and toxicant-induced biomarker signatures using microarrays in Biomarkers in Toxicology, 2nd Ed. Ramesh Gupta (ed).  ISBN: 9780128146552

Dostie, K. E.*, Thees, A.V*., and M.A. Lynes (2018) Metallothionein: a Novel Therapeutic Target for Treatment of Inflammatory Bowel Disease. Curr Pharm Des (*co-first authors) 24(27):3155-3161. doi: 10.2174/1381612824666180717110236.

Bhandari, S., Melchiorre, C., Dostie, K., Laukens, D., Devisscher, L., Louwrier, A., Thees, A., and Lynes, M.A. (2017) Detection and Manipulation of the Stress Response Protein Metallothionein. Curr. Protoc. Toxicol. 71:17.19.1-17.19.28. doi: 10.1002/cptx.17