University of Connecticut
Department of Molecular & Cell Biology
91 North Eagleville Road, Unit-3125
Biology/Physics Building 205
Storrs, CT 06269-3125
Telephone: (860) 486-4333
Fax: (860) 486-4331
Education: Ph.D., University of California; Post-doctoral study, Stanford University.
Research Interests: Characterization of macromolecular interactions using analytical ultracentrifugation and related biophysical techniques. Double-stranded RNA activated protein kinase (PKR); interferon antiviral defense pathway; trp RNA-binding attenuation Protein (TRAP).
Mayo, C.B. and Cole, J.L. (2017) Interaction of PKR with single-stranded RNA. Sci. Rep.7, 3335
Mayo, C.B., Wong, C.J., Lopez P.E., Lary, J.W., Cole, J.L. (2016) Activation of PKR by short stem-loop RNAs containing single-stranded arms. RNA, DOI:10.1261/rna.053348.115.
Husain, B., Mayo, C. and Cole, J.L. (2015) Role of the interdomain linker in PKR activation. Biochemistry, in press, DOI:10.1021/acs.biochem.5b01171.
Husain, B., Hesler, S. and Cole, J.L. (2015) Regulation of PKR by RNA: Formation of active and inactive dimers. Biochemistry 54, 6663-6672.
Launer-Felty, K., Wong, C.J. and Cole, J.L. (2014) Structural analysis of Adenovirus VAI RNA defines the mechanism of inhibition of PKR. Biophysical Journal 108, 748-757.
Kaus, K., Lary, J.W., Cole, J.L. and Olson, R. (2014) Glycan specificity of the Vibrio vulnificus hemolysin lectin outlines evolutionary history of membrane targeting by a toxin family. J. Mol. Biol. 426, 1285-1295
Wowor, A.J., Yan, Y., Auclair, S.M., Yu, D., Zhang, J., May, E.R., Gross, M.L., Kendall, D.A. and Cole, J.L. (2014) Analysis of SecA Dimerization in Solution. Biochemistry 53, 3248-3260.
Launer-Felty, K. and Cole, J.L. (2014) Domain interactions in Adenovirus VAI mediate high-affinity PKR binding.J. Mol. Biol. 426, 1285-1295.
Yu, D., Wowor, A., Cole, J.L., and Kendall, D.A. (2013). Defining the Escherichia coli SecA Dimer Interface Residues through in Vivo Site-specific Photo-crosslinking.J. Bacteriol. 195, 2817-2825.
Ehlinger, A., Park, S., Fahmy, A., Lary, J.W., Cole, J.L., Finely, D., and Walters, K.J. (2013). Conformational Dynamics of the Rpt6 ATPase in Proteasome Assembly and Rpn14 Binding.Structure 21, 735-765
Cole, J.L, Correia, J.J. and Stafford, W.F. (2011) The use of analytical sedimentation velocity to extract thermodynamic linkage Biophys. Chem. 159, 120-128.
Wong, C.J., Launer-Felty, K. and Cole, J.L. (2011) Analysis of PKR-RNA interactions by sedimentation velocity. Methods Enzymol. 488, 59-79.