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Professor Kenneth M. Noll University of Connecticut Molecular & Cell Biology, BSP 407 91 North Eagleville Road, Unit 3125 Storrs, CT 06269-3125 Telephone: (860) 486-4688 Fax: (860) 486-4331 E-Mail: kenneth.noll@uconn.edu

Education: Ph.D. University of Illinois

Research Interests: The physiology and evolution of hyperthermophilic organisms. Of particular interest are the organisms of the bacterial order Thermotogales. Recent work has focused on the evolution of sugar transporters in this lineage and the horizontal transport of genes encoding transporters between members of the Thermotogales and archaea.

Selected Publications:
For a complete, up-to-date list, consult PubMed at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed.

Nanavati, D. M., T. N. Nguyen, and K. M. Noll. Substrate specificities and expression patterns reflect the evolutionary divergence of maltose ABC transporters in Thermotoga maritima . J. Bacteriol. 187:2002-9. 2005.

Nguyen, T. N., A. D. Ejaz, M. A. Brancieri, A. M. Mikula, K. E. Nelson, S. R. Gill, and K. M. Noll. Whole-genome expression profiling of Thermotoga maritima in response to growth on sugars in a chemostat. J. Bacteriol. 186:4824-8. 2004.

Nanavati, D., K. M. Noll, and A. H. Romano. Periplasmic maltose- and glucose-binding protein activities in cell-free extracts of Thermotoga maritima . Microbiology 148:3531-7. 2002.

Yu, J. S., M. Vargas, C. Mityas, and K. M. Noll. Liposome-mediated DNA uptake and transient expression in Thermotoga. Extremophiles 5:53-60. 2001.

Yu, J. S. and K. M. Noll. Phosphoglycerate kinase-triose-phosphate isomerase complex from Thermotoga neapolitana. Methods Enzymol. 331:78-89. 2001.

Guipaud, O., E. Marguet, K. M. Noll, C. B. de la Tour, and P. Forterre. 1997. Both gyrase and reverse gyrase are present in the hyperthermophilic bacterium Thermotoga maritima. Proc. Natl. Acad. Sci. USA 94:10606-10611.

Noll, K. M. and M. Vargas. 1997. Recent advances in genetic analyses of hyperthermophilic archaea and bacteria. Arch. Microbiol. 168:73-80.

Yu, J.-S. and K. M. Noll. 1997. Plasmid pRQ7 from the hyperthermophilic bacterium Thermotoga species strain RQ7 replicates by the rolling circle mechanism. J. Bacteriol. 179:7161-7164.

Galperin, M., K. M. Noll, and A. R. Romano. 1996. Co-regulation of beta-galactoside uptake and hydrolysis by the hyperthermophilic bacterium Thermotoga neapolitana. Appl. Environ. Microbiol. 63:969-972.

Galperin, M., K. M. Noll, and A. R. Romano. 1996. The glucose transport system of the hyperthermophilic anaerobic bacterium Thermotoga neapolitana. Appl. Environ. Microbiol. 62:2915-2918.

Vargas, M. and K.M. Noll. 1996. Catabolite repression in the hyperthermophilic bacterium Thermotoga neapolitana is independent of cAMP. Microbiology. 142:39.

Yu, J.-S. and K.M. Noll. 1995. The hyperthermophilic bacterium Thermotoga neapolitana possesses two isozymes of the 3-phosphoglycerate kinase/triosephosphate isomerase fusion protein. FEMS Microbiol. Lett. 131: 307-312.