Professor Andrei T. Alexandrescu
Education: Ph.D. University of Wisconsin-Madison; Postdoctoral study, Oxford University; Johns Hopkins University Medical Institutes
Research Interests: High-resolution solution NMR investigations of protein structure, folding, dynamics, and association;
Amyloid fibrils: Amylin (type 2 diabetes), A-beta (Alzheimer's Disease), alpha-synuclein (Parkinson's Disease), SEVI (HIV infectivity);
Protein folding intermediates, protein structure conservation, and evolution of protein structure.
[Click here to get nearly full publication list.]
Sheftic, S.R., Garcia, P.P., White, E., Robinson, V.L., Gage, D. & Alexandrescu, A.T. (2012) “Nuclear Magnetic Resonance Structure and Dynamics of the Response Regulator Sma0114 from Sinorhizobium meliloti”. Biochemistry 51, 6932-6941.
Sheftic, S.R., Snell, J. M., Jha, S. & Alexandrescu, A.T. (2012) “Inhibition of Semen-derived Enhancer of Virus Infection (SEVI) fibrillogenesis by physiological zinc and copper concentrations”, European Biophysics Journal, in press. DOI: 10.1007/s00249-012-0846-0
Jha, S., Patil, S.M., Gibson, J., Nelson, C.E., Alder, N.N., Alexandrescu, A.T. (2011) "Mechanism of amylin fibrillization enhancement by heparin". J. Biol. Chem. 286, 22894-22904. doi:10.1074/jbc.M110.215814
Patil, S.M., Mehta, A., Jha, S. & Alexandrescu, A.T (2011) “Heterogeneous amylin fibril growth mechanisms imaged by Total Internal Reflection Fluorescence Microscopy". Biochemistry 50, 2808-2819. DOI: 10.1021/bi101908m