Crystal Morales-Del Valle


Assistant Professor-In-Residence

University of Connecticut
Department of Molecular and Cell Biology
Hartford Campus
10 Prospect St., Rm 314D
Hartford, CT. 06103

Telephone: 959-200-3841
crystal.morales@uconn.edu

Education:
Postdoctoral Fellow (Immunology) University of Connecticut Health
Ph.D. (Biomedical Sciences – Immunology) University of Connecticut Health Center & visiting graduate student at the Medical University of South Carolina
B.A. (Biology, Religion minor) Boston University

Research Interests:  My broad research focus is on cellular and molecular immunology. I am interested in Drosophila innate immunity, and defining the chaperones of Toll and integrins. Another area of emphasis is the development of novel adjuvants with greater specificity and efficacy. These adjuvants will further be tested in conjunction with cancer immunotherapy techniques for their impact on the immune response in various cancers.

Selected Publications:

Morales C, Rachidi S, Hong F, Sun S, Ouyang X, Wallace C, Zhang Y, Garret-Mayer E, Wu J, Liu B, Li Z. “Immune chaperone gp96 drives the contributions of macrophages to inflammatory colon tumorigenesis,” Cancer Research, 2014; 74(2): 1-14. PMID: 24322981

Liu B, Staron M, Hong F, Wu X, Sun S, Morales C, Crosson C, Tomlinson S, Kim I, Wu D, Li Z. “Essential roles of grp94 in gut homeostasis via chaperoning canonical wnt pathway,” PNAS, 2013; 110(17): 6877-82. PMCID: PMC3637754

Sugrue ML, Vella KR, Morales C, Lopez ME, Hollenberg AN. “The thyrotropin-releasing hormone gene is regulated by thyroid hormone at the level of transcription in vivo,” Endocrinology, 2010; 151(2): 793-801. PMCID: PMC2817611

Morales C, Wu S, Yang Y, Hao B, Li Z. “Drosophila glycoprotein 93 is an ortholog of mammalian heat shock protein gp96 (grp94, HSP90b1, HSPC4) and retains disulfide bond-independent chaperone function for TLRs and integrins,” Journal of Immunology, 2009; 183(8): 5121-28. PMCID: PMC2856694

Astapova I, Lee LJ, Morales C, Tauber S, Bilban M, Hollenberg AN. “The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo,” Proceedings of the National Academy of Sciences of the USA, 2008; 105(49): 19544-49. PMCID: PMC2614797